Cannot suggest
Broodhollow strongly enough, especially here on SA. I don't know if any other webcomic has made me uncomfortable in the same way a Lovecraft story might, the way this one does. Get sucked in on a quiet, dark night.
Schlock is my favorite semi-hard scifi comic, very clever, very creative. Aliens made out of non-baryonic matter, Stargates that are also in the wrong hands cloning devices, all manner of AI...Hard to say where to start though, as it does start bad and corny, but some of the early storylines are relevant. Pick a spot.
Dr. McNinja is just...damned good. He punches Dracula in the nose and runs away. His secretary is a gorilla. His advisor was a Ben Franklin Clone. And somehow you never get yanked out of the reality.