Some interesting theories about the ascendancy of mankind being attributed to early humans with social handicaps - OCD, Asperger, anxiety, etc. The idea being that those who were making fire, tools, traps, early science, were the marginalized antisocials who couldn't stand the idiot chiefs dancing around the fire. Even today, and throughout history, there are lots of examples of imperfect individuals making the highest contributions to science at large.
There's also a lot of danger trying to weed out seemingly useless genetic combinations from the gene pool. A more obvious example being someone heterozygous for sickle cell is rendered immune to malaria, while homozygous has deadly sickle cell anemia.
It is, unfortunately, rather difficult to predict what genes serve no purpose.
Though we'd probably need a populations of a several million and entire planets to do it on, studying the effects of completely removing specific things from the genetic pool and watching how it turns out over a few dozens generations would probably yield truly fascinating results.
Maybe until that's possible, a subclass of 'not humans' can be kept around with all of evolution's genetic baggage in case of emergency, and the rest of 'true humanity' can be freed from the bondage of nature.