Wutteat perhaps isn't a Big Question, but I can't help but be amused at the thought of that big-arse immortal dragon flying around blind and deaf.
Also, Ieva had to have been corrupted. The Bardic Priest, with his whack eye seems pretty nefarious ... and he does pop up in Akka's dreams ...
We know there was treachery in Nimeric's court at Tryse as well.
It may be important that all non-inchie members of the consult are sorcerers. Remember the fate of Mekeritrig's (non-quya) companions who also looked into the IF?
Mek tricked Nil'Giccas into killing them, then bid his time for 2000 years until Shae helped him bring down the barricades.
The pre-sorcery inchies might be damned for neuro-tweaking away their compassion etc, if Kellhus is correct.
So I think the question of whether Ieva was a witch is a good one if she has looked into the IF, because it would clear up that question about sorcery and damnation a great deal for me.
W/regards to Serwe and gender issues, I believe that is already fairly plain if you look for it. Men have a higher spiritual value in Earwa. This isn't a good thing. All the agencies in the outside that vie for their souls are affiliated with damnation, ciphrang and the hundred gods (which are viewed by the inchies, the nonmen and the cishaurim as super powerful demons). Having a higher spiritual value just means you get are in fact more likely to become damned.
Bakker has been ramming us in the face with IMPORTANT female characters. But every one of them is an archetype that suffers at the hands of men; they are unambiguously female-only archetypes seen throughout all historical patriachal cultures. This is what has drawn the most criticism, as I see it. I don't think it is possible to make the statement that Bakker intends by using females that are merely adopting traditional male roles, at least not too early. (I'm somewhat expecting an ignoble ending for Serwa in TUC)
Serwe is so innocent she basically anoints Kellhus - and then her death breaks him.
Esmemnet's situation and potential are presented as the cause for Kellhus initiating changes to females' social status. She becomes the pre-eminent example of mobility and change within rigid caste structures. The foreshadowing is plain in PoN where we discover that Angreashal, the first 'great prophet' was married to Esmenet.
Mimara understands redemption implicitly via the judging eye, and I believe her character arc that most distinctly shows that females in Earwa are very important - even if they are valued less in the afterlife.
This is a theme that we see again and again - from the loss of the Cunoroi women, to Serwe's burning heart, to Esmenet being chosen to rule instead of Maitha. In every instance, the feminine is the key to redemption.