For some reason I was skeptical when I first heard about this show, despite enjoying and sometimes outright loving Community. But once I finally checked it out (initially at sciborg's request, I believe) I was converted. It's consistently funny, occasionally heartfelt, and the sci-fi aspects are fucking GREAT. Every single episode introduces at least one (though usually several) sci-fi idea and runs with it, hard. They take basic ideas and get really far into them, more-so than many live-action sci-fi stuff. And the family dynamic is quite good, with a lot of potential for the future if they're willing to break the mold and go in unique directions.
Can't wait for season two...has that been announced at all?
Probably the most interesting animated comedy of recent years was Xavier: Renegade Angel - n64 era computer graphics, a mutant hippie and some of the most bizarre fucked up humour imaginable. Only cartoon I know of that features plotlines about arab terrorists turning out to be "Baudrillardrian simulacra".
It may be the single greatest stoner tv show ever. Although its so fucked up its more like acid and DMT.
Xavier: Renegade Angel is brilliant in my opinion. One of the most overlooked animated shows of all time in my probably -- though it's understandable why. You almost need to get the "rules" of the show before it works, and every episode requires at least one re-watch I think to seriously grasp all what's going on. The wordplay and interwoven themes are so dense and cryptic that it genuinely requires "work" to actually get it. That probably sounds pretentious as hell but it's my honest opinion on it.
Keep in mind this was made by the same people who did Wonder Shozen, which I've only seen bits of but have heard was pretty fantastic.