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The question of how we might begin to grasp the entirety of the organ that generates our minds has been pressing me for a while. Like most neuroscientists, I’ve had to cultivate two clashing ideas: striving to understand the brain and knowing that’s likely an impossible task. I was curious how others tolerate this doublethink, so I sought out Jeff Lichtman, a leader in the field of connectomics and a professor of molecular and cellular biology at Harvard.Lichtman’s lab happens to be down the hall from mine, so on a recent afternoon, I meandered over to his office to ask him about the nascent field of connectomics and whether he thinks we’ll ever have a holistic understanding of the brain. His answer—“No”—was not reassuring, but our conversation was a revelation, and shed light on the questions that had been haunting me. How do I make sense of gargantuan volumes of data? Where does science end and personal interpretation begin? Were humans even capable of weaving today’s reams of information into a holistic picture? I was now on a dark path, questioning the limits of human understanding, unsettled by a future filled with big data and small comprehension.