Well if we have a soul I figure most (all?) chances on answering questions like "can you upload your self" would be off. But we could ask again why the structure of nervous system (or even entire body) is the way it is, and what makes us think a different structure would "catch" consciousness?
But computationalists who support mind uploading, from what I understand, believe all facts are physical facts. [Their disbelief in souls is the motivation for uploading] But they uplift the position of structure, or matter's "Form" as Aristotle would say. Or rather it might be better to say they privilege processes, and claim that a complete enough simulation will provide then necessary duplication of said processes.
But the processes in the physical world would be the workings of the Turing Machine, the stuff of Frogger - CPUs, Registers, etc...hardly the stuff of cells aka the stuff of Frog.