Interesting. I do think science can proceed as a metaphysically neutral exploration of a subset of reality, so long as we don't confuse it with the totality.
Well, science (at least physics, biology and chemistry) would seem to be concerned with "thing-in-themselves" rather than things-as-appearing. So, for example, what we would want is the "rules of gravitation" as-they-are, not as-they-appear. Because, as seems to be the case, what we "see" as gravity's function on earth (basically Newton) is not gravity's function as-it-is, which apparently is what Eisenstein's Relativity gives us.
So, science's sort of "evolutionary" approach, because we cannot (along the Kantian lines) get at the Noumena, as Noumea in-itself, we sort of "peel back" the phenomena and draw closer and closer to Noumea-in-itself, even though, like Zeno's paradox, we will never get there. Still, the idea seems "correct" at an "effective" level, that is, the level of "usefulness."
So, what the hell am I getting at? I'm not sure. But maybe it's that "meaning" (to me) is Phenomenological, that means (to me) eminently Subjective and so, it not a specifically quality of Noumena in-themselves, rather, Noumena as they appear, Phenomenologically. And so, I think it is "correct" to a degree to specfically not "presuppose" meaning, in the same way that it would seem "correct" to me to not presuppose that objects only exist Phenolomenologically (even though there is no way to prove that).
I'm not sure I am even making sense now though.