I love the idea of a Transhuman RPG but Eclipse Phase has stuff like the following that I just cannot wrap my mind around:
Transhumanity’s grasp of neuroscience extends to scanning and copying a mind, but the most intricate workings of memory are still imperfectly understood. Making precise edits to individual portions of a neural network (to alter recollections, skills, and the like) is still a black art. The difficulty with neural pruning is that taking a weed whacker to the tree of memory isn’t an exact science.
Keep in mind the RPG allows the mind to live in virtual space...so somehow there has to be a way to upload a mind, preserve its memories, but also not fully understand how memory works...